Detailed view for TcCLB.506679.30

Basic information

TDR Targets ID: 45749
Trypanosoma cruzi, C2 domain containing protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.5469 | Length (AA): 1065 | MW (Da): 117956 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
556 666 2chd (A) 386 498 23.00 0.000000000039 0.47 0.35 -0.21
938 1030 1rlw () 21 112 24.00 0.0000000079 0.36 0.28 -0.05
140 263 5j0l (A) 2 124 23.00 0.096 0.39 0.355432 -0.87
157 329 4uos (A) 1 184 17.00 0.0022 0.25 0.401441 -1.31
297 382 4g9y (A) 56 136 35.00 0.82 0.09 0.258651 0.6
554 672 4ts6 (A) 840 962 26.00 0.0000012 0.85 0.447737 -0.68
569 680 1v27 (A) 23 138 26.00 0 0.98 0.428364 -0.27
569 687 3kwt (A) 691 814 29.00 0.00072 0.82 0.326737 -0.3
569 681 2dmg (A) 26 141 19.00 0 0.48 0.278303 -0.23
931 1056 3pyc (A) 9 138 18.00 0 0.65 0.22151 -0.54
936 1056 1wfj (A) 11 127 21.00 0 0.83 0.349815 -0.57
937 1059 5a51 (A) 37 149 34.00 0.8 0.07 0.175393 1.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_167681)

Species Accession Gene Product
Trypanosoma brucei gambiense Tbg972.10.6420   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.5260   C2 domain containing protein, putative
Trypanosoma brucei Tb11.v5.0497   hypothetical protein, conserved
Trypanosoma brucei Tb11.v5.0250   C2 domain containing protein, putative
Trypanosoma congolense TcIL3000_10_4400   C2 domain containing protein, putative
Trypanosoma cruzi TcCLB.506679.30   C2 domain containing protein, putative

Essentiality

TcCLB.506679.30 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.5260 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.5260 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.5260 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.5260 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0058 0.5 0.5
0.005 0.2612 0.5
0.0107 0.5 0.5
0.0072 0.2639 1
0.0125 0.3893 0.3893
0.0109 0.4866 0.5
0.0057 0.3491 0.5
0.0071 0.2549 1
0.0018 0.5 0.5
0.0121 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.506679.30 (Trypanosoma cruzi), C2 domain containing protein, putative
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